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A new species is formed when:

[A].	An individual with new genotype is formed due to exchange of chromosomal segments during crossing over in gametogenesis	[B].	Genotypic changes accumulated in a population which result in its reproductive isolation
[C].	Variants with new phenotypes are produced owing to new genetic combinations occurring during reproduction	[D].	Homologous chromosomes exchange segments during crossing over in gametogenesis

Answer: Option B